A comparative study of the succinic dehydrogenase-cytochrome system in heart muscle and in kidney.

Studies on the Terminal Electron Transport System

The present communication is devoted to the description of the isolation, properties, and composition of a particulate unit which we shall refer to as the succinic dehydrogenase complex (SDC). The working hypothesis underlying this and subsequent communications in this series is that SDC is a unit of enzymatic action in the same sense as any well defined soluble enzyme. Since the discovery of s...

The Metabolism of the Kidney in Experimental Renal Hypertension

These investigations are part of an attempt to study and interpret the intermediary metabolism of the kidneys in experimental renal hypertension. Hypertension was produced in dogs by the clamping procedure of Goldblatt and associates or by the silk perinephritis method of Page. Enzymatic studies were made by means of Warburg's manometric method. Cytochrome c was in addition determined spectroph...

Succinic Acid Monoethyl Ester and Metformin Regulates Carbohydrate Metabolic Enzymes and Improves Glycemic Control in Streptozotocin-Nicotinamide Induced Type2 Diabetic Rats

Objective. Succnic acid mono ethyl ester (EMS) was recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. In the present study the effect of EMS and Metformin on the activities of carbohydrate metabolic enzymes in streptozotocinnicotinamide induced type 2 diabeteic model was investigated. Methods. EMS were injected intraperitonially at doses 2...

Short Communication:A comparative study on manganese accumulation in liver, kidney, fatty tissues including muscle of rainbow trout (Oncorhynchus mykiss) fed with different levels of manganese in the diet

The Kinetics and Inhibition of Cytochrome Components of the Succinic Oxidase System

In Paper I (l), methods were described for measuring the changes of optical density of a turbid heart muscle preparation on reduction by succinate. By repeating such experiments at various wave-lengths, the difference spectrum between the steady state oxidized and the reduced forms of the heart muscle preparation is plotted. Such spectra clearly show the recognized absorption bands of the cytoc...